Hyponatremia
Renal disorders    All Diseases     eMedicine
General Info
HPI/Physical
Patients can present with altered mental status. This is very common in older patients and is ususally chronically low. The main concern is treating it before it gets low enought to cause seizures and not correcting too quickly to avoid Central Pontine Myelinolysis . Symptoms:
Abdominal pain, Headache, Agitation, Hallucinations, Cramps, Confusion. Lethargy, Seizures, Polydipsia, Polyuria, Diarrhea, Vomiting, Dyspnea, Swelling
Differential 
1. Osmolarity
Hypertonic (>300mOs/Kg) Isotonic (275-300mOs/Kg)
Hypotonic (<275mOs/Kg)
Hyperglycemia
Increase sodium by 1.6 for every 100mg/dL over 100
Mannitol
Uremia
Due to lab artifact, rare
Hyperlipidemia
Paraproteinemia
Multiple Myeloma, MGUS, Leukemia
See below
2. Hypotonic Hyponatremia: Volume Status
Volume Overload:
Euvolemic:
Volume Depleted (Dehydrated):
Water overload and salt overload, body thinks your empty when you are not.
Urine Na > 20, FeNa > 1% points to RF
Urine Na < 10, FeNa < 1% points to others
This is due to excessive free water intake or the inability to excrete free water
Uosm > 100 points to inability to excrete
Uosm < 100 points to excess free water intake
Your body thinks that you are empty and you are
Urine Na < 10, FeNa < 1% non renal
Urine Na > 20, FeNa > 1% renal
Congestive heart failure
Cirrhosis
Nephrotic Syndrome
Renal Failure
Excess intake:
Psychiatric polydipsia
Hypothalamic infarct
Inability to excrete free water:
Addison's disease
Hypothyroid
Reset Osmostat
Potomania
SIADH

Gastrointestinal: 3rd spacing: Renal:
Diarrhea
Vomiting
Fistula
Ostomy
Peritonitis
Pancreatitis
Sepsis
Burns
Stevens-Johnson syndrome
TEN
Exzema
Psoriasis
Diuretics
Renal tubular acidosis
Primary hypoaldosteronism
Insterstitial nephropathy



Tests/Diagnosis
Management
Disposition
Serum sodium: hyponatremia
Urine sodium
Serum creatinine
Urine creatinine
Serum osmolarity
Urine osmolarity
    If patient on diuretic use BUN
Urine urea
Serum urea

Fractional excretion Na (FeNa)
Fractional excretion Urea (FeUrea)
- Treat underlying condition
- Hypertonic saline (3%NS): Given if paitent is seizing or unstable, careful adminitration due to Central Pontine Myelinolysis risk

- Normal saline: if dehydrated
Sodium Deficit Formula
- Water restriction: if fluid overload or euvolemic

- Discharge if mild or chronic with medicine follow up

- Admit to medicine if needed

- Admit to ICU if seizing